个人简介
工作单位:威澳门尼斯人官网欢迎您/威澳门尼斯人官网欢迎您
单位地址:昆明市呈贡区大学城东外环南路
邮 编:650500
电子邮箱:jwsun@ynu.edu.cn
一、 个人情况介绍
博士、教授、博士生导师。2019年入选“云南省千人计划”青年人才项目资助,2021年入选“云南省杰出青年”基金项目资助。以通讯/第一作者身份在Journal of Cell Biology、Oncogene、Journal of Biological Chemistry、Journal of cell science等国际一流学术期刊发表近20篇。中国生物物理学会线粒体分会理事,国家自然科学基金委同行评议专家,云南省自然科学基金评审专家库专家。现主持国家自然基金面上项目、云南高层次人才青年项目、云南省“杰出青年”项目等。
二、 教育经历
2006.09-2010.11 中国科学院遗传发育所 博士
2003.09-2006.07 青岛农业大学 硕士
1999.09-2003.07 青岛农业大学 学士
三、 工作经历
2019.01-至今 威澳门尼斯人官网欢迎您 威澳门尼斯人官网欢迎您 教授 博士生导师
2015.05 -2018.12 华南农业大学 威澳门尼斯人官网欢迎您 教授 博士生导师
2014.12 -2015.04 Moffitt癌症研究中心 研究科学家
2010.12 -2014.11 Moffitt癌症研究中心 博士后
四、研究方向
1. 线粒体功能调控失调在肿瘤发生中作用及机制
2. 肿瘤转移相关基因的筛选与机制研究
3. 钙池操纵的钙内流(SOCE)介导线粒体功能调控癌症发生恶化及肿瘤抗药性的分子机制
五、承担的科研项目
1. 国家自然基金面上项目(2023-2026),金额:52万,主持。
2. 国家自然基金地区项目(2023-2026),金额:32万,主要负责(团队成员主持)。
3. 云南省科技厅重大科技专项计划(2023-2026),子课题负责人,个人分配金额:60万
4. 云南省高层次青年人才后续基金项目(2022-2025)金额:70万,主持
5. 云南省杰出青年基金(2021-2024),金额:50万,主持
6. 威澳门尼斯人官网欢迎您双一流创新团队(2021-2024)金额:200万,主持
7. 云南省科技厅重大科技专项(2021—2024),个人分配金额:50万,参与
8. 云南省科技厅-威澳门尼斯人官网欢迎您双一流联合基金(2019-2022)金额:65万,主持,已结题。
9. 国家自然基金面上项目(2017-2020),金额:60万,主持,已结题。
六、实验室成员
博士生: 刘享享(2020级),郝庆刚(2021级),白韦钰(2022级), 董瑞(2023级)
硕士生:韩冰心,常栋,邱少卿,姚欣怡,肖惠琳,张智猛,周欣怡
留学生: Ksenia Golub(苏珊,2022级)
已毕业研究生:
博士生:
(1) 2020级:桑磊(获2022年国家奖学金,2021年云南省奖学金)
(2) 2016级:康嘉欣(获2018年国家奖学金)
硕士生:
(1) 2020级:董瑞(获2022年国家奖学金,威澳门尼斯人官网欢迎您读博),严程浩(2023年云南省优秀毕业生;湖南大学读博),陆梅(延安医院工作);
(2) 2018级:白韦钰(威澳门尼斯人官网欢迎您读博);商荣磊;孙瑞;
(3) 2016级:胡元昭(海南大学博士);许安祺;
博士后:王兴顺;
七、 研究论文(*通讯作者)
1. Jie Li #, Muhammad Ahmad#, Lei Sang#, Yahui Zhan#, Yibo Wang, Yonghong Yan, Yue Liu, Weixiao Mi, Mei Lu, Yu Dai, Rou Zhang, Meng-Qiu Dong, Yun-Gui Yang, Xiaohui Wang*, Jianwei Sun*, Jing Li*. O-GlcNAcylation promotes the cytosolic localization of the m6A reader YTHDF1 and colorectal cancer tumorigenesis. Journal of Biological Chemistry. 2023 Apr 20;104738. doi: 10.1016/j.jbc.2023.104738
2. Lei Sang#, Rui Dong#, Rui Liu, Qinggang Hao, Weiyu Bai, Jianwei Sun*. Caenorhabditis elegans NHR-14/HNF4α regulates DNA damage-induced apoptosis through cooperating with cep-1/ p53. Cell Communication & Signaling. 2022 Sep 1;20(1):135. doi: 10.1186/s12964-022-00920-5.
3. Junling Shen#, Jilong Yang#, Lei Sang, Rui Sun, Weiyu Bai, Chao Wang, Yan Sun*, Jianwei Sun*. PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas. Cancer Biology and Medicine. 2021 Sep 28;19(8):1211-1223. doi: 10.20892/j.issn.2095-3941.2020.0294
4. Lei Sang#, Ying-jie He#, Jiaxin Kang#, Hongyi Ye, Weiyu Bai, Xiao-dong Luo* and Jianwei Sun*. Mitochondrial deoxyguanosine kinase (DGUOK) regulates NAD+ Biogenesis Independent of mitochondria complex I activity. Frontiers in Oncology 2020 Dec 18;10:570656. doi: 10.3389/fonc.2020.570656
5. 孙瑞, 胡元昭, 商荣磊, 白韦钰 孙建伟*. 线粒体脱氧鸟苷激酶在肺癌肿瘤发生中的作用及机制研究 (中国科学:生命科学) . 2019, 49(7): 893-901
6. Jian Wang, Junling Shen, Kaili Zhao, Jinmeng Hu, Jiuxing Dong and Jianwei Sun*. STIM1 overexpression in hypoxia microenvironment contributes to pancreatic carcinoma progression. Cancer Biology and Medicine. 2019 Feb;16(1):100-108. doi: 10.20892/j.issn.2095-3941.2018.0304
7. Fujian Lu#, Jianwei Sun#, Qiaoxia Zheng, Jinghang Li, Yuanzhao Hu, Peng Yu, Huifang He, Yan Zhao, Xianhua Wang, Shengyu Yang* and Heping Cheng*. Imaging elemental events of store-operated Ca2+ entry in invading cancer cells with plasmalemmal targeted sensors. Journal of Cell Science (2019) 132, jcs224923. doi:10.1242/jcs.224923.
8. Jiaxin Kang#, Jian Wang#, Zhuang Yao#, Yuanzhao Hu, Shijie Ma,Qin Fan,Yan Sun* and Jianwei Sun*. Fascin induce melanoma tumorgenesis and stemness through regulating TAZ stability. Cell Communication & Signaling. 2018 Jul 3;16(1):37. doi: 10.1186/s12964-018-0250-1.
9. Shengchen Lin#, Shuang Lu#, Mentor Mulaj, Bin Fang, Tyler Keeley, Lixin Wan, Jihui Hao, Martin Muschol, Jianwei Sun* and Shengyu Yang*. Monoubiquitination Inhibits the Actin Bundling Activity of Fascin. Journal of Biological Chemistry. 2016 Dec 30;291(53):27323-27333.(*共同通讯作者)
10. Jaw-Yuan Wang#, Jianwei Sun#, Ming-Yii Huang, Ming-Feng Hou, Yu-Shiuan Wang, Yan Sun, Yao-Ting Tsai, Huifang He, Shengchen Lin, Shengyu Yang, and Wei-Chiao Chang. STIM1 Overexpression promoted Colorectal Cancer Progression, Cell Motility and COX-2 Expression. (#共同第一作者) Oncogene, 2015 Aug 13;34(33):4358-67.
11. Jianwei Sun, Fujian Lu, Huifang He, Junling Shen, Jane Messina, Rahel Mathew, Dapeng Wang, Amod A. Sarnaik, Wei-Chiao Chang, Minjung Kim, Heping Cheng, and Shengyu Yang. STIM1- and Orai1-mediated Ca2+ oscillation orchestrates invadopodium formation and melanoma invasion. Journal of Cell Biology. 2014 Nov 24, 207(4): 535-548. (Highlighted by JCB editor: http://jcb.rupress.org/content/early/2014/11/10/jcb.2074iti3)
12. Jianwei Sun, Huifang He, Smitha Pillai, Yin Xiong, Sridevi Challa, Liyan Xu, Srikumar Chellappan and Shengyu Yang. GATA3 Transcription Factor Abrogates Smad4 Transcription Factor-mediated Fascin Overexpression, Invadopodium Formation, and Breast Cancer Cell Invasion. Journal of Biological Chemistry. 2013 Dec 27;288(52):36971-82.
13. Jianwei Sun, Huifang He, Yin Xiong, Shuang Lu, Junling Shen, Anna Cheng, Wei-Chiao Chang,Ming-Feng Hou, Johnathan M. Lancaster, Minjung Kim and Shengyu Yang. Fascin Protein Is Critical for Transforming Growth Factor Protein-induced Invasion and Filopodia Formation in Spindle-shaped Tumor Cells. Journal of Biological Chemistry 2011, 286(45): 38865–38875.
14. Mei Yang#, Jianwei Sun#, Xiaojuan Sun, Qinfang Shen, Zhiyang Gao and Chonglin Yang. Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-induced Apoptosis. PLoS Genetics 2009 5(6):e1000514. (#共同第一作者)
八、 综述论文(*通讯作者)
1. 姚欣怡,董瑞,郝庆刚,沈俊岭,刘楠,孙建伟. VPS35在肿瘤发生与转移中的作用及机制研究. (中国科学.生命科学)2023 (In Press)
2. Cheng-hao Yan, Wei-yu Bai, Zhi-meng Zhang, Jun-ling Shen, You-jun Wang, Jian-wei Sun. The roles and mechanism of STIM1 in tumorigenesis and metastasis. Yi Chuan. 2023,45(5):doi: 10.16288/j.yczz.23-035.
3. Dong Chang, Xiang-Xiang Liu , Rui Liu , Jian-Wei Sun. The role and regulatory mechanism of FSCN1 in breast tumorigenesis and progression. Yi Chuan. 2023 Feb 20;45(2):115-127. doi: 10.16288/j.yczz.22-346.
4. Lei Sang#, Xingshun Wang#, Weiyu Bai, Junling Shen*, Yong Zeng*, Jianwei Sun*. The Role of Hepatocyte Nuclear Factor 4α (HNF4α)in Tumorigenesis. Frontiers in Oncology 2022 Sep 28;12:1011230. doi: 10.3389/fonc.2022.1011230.
5. Qing-Gang Hao, Feng-Gui Sun , Cheng-Hao Yan , Jian-Wei Sun*. Progress on the role and mechanism of MT1-MMP in tumor metastasis. Yi Chuan. 2022 Sep 20;44(9):745-755. doi: 10.16288/j.yczz.22-213.)
6. 桑磊,董瑞,陆梅,孙建伟* Fascin:恶性肿瘤不良预后标志. 现代肿瘤医学. 2021
7. Jianwei Sun, Shengchen Lin, Tyler S Keeley, Shengyu Yang. Disseminating Melanoma Cells Surf on Calcium Waves. Molecular & Cellular Oncology. 2015;2(4):e1002714. doi: 10.1080/23723556.2014.1002714.
九、专利
1. 孙建伟,桑磊,高亚可,董瑞,沈俊岭,陈慧诚. 一种与动物不孕相关的基因、sgRNA及应用和构建动物模型的方法. 申请号:CN113201515B;专利号:ZL 2021 1 0628285.3. 2022
2. 孙建伟,刘享享,董瑞,桑磊,白韦钰,韩冰心,常栋,张旭,沈俊岭. 一种基因敲除能够引起癫痫症状发生的动物模型构建的方法及应用. 申请号:202211408689.2 2023